Mitochondrial ferritin expression in erythroid cells from patients with alpha-thalassaemia
نویسندگان
چکیده
منابع مشابه
Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia.
The sideroblastic anemias are characterized by ring sideroblasts, that is, red cell precursors with mitochondrial iron accumulation. We therefore studied the expression of mitochondrial ferritin (MtF) in these conditions. Erythroid cells from 13 patients with refractory anemia with ring sideroblasts (RARS) and 3 patients with X-linked sideroblastic anemia (XLSA) were analyzed for the distributi...
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متن کاملSerum ferritin in children with thalassaemia regularly transfused.
A controlled trial of continuous chelation therapy in regularly transfused children with homozygous beta-thalassaemia has been in progress at the Hospital for Sick Children since April 1966. In the sixth and seventh years of the trial the effect of this treatment on iron overload has been assessed by estimating serum ferritin levels and liver iron concentrations in both chelator-treated and con...
متن کاملAn insulator with barrier-element activity promotes alpha-spectrin gene expression in erythroid cells.
Understanding mechanisms controlling expression of the alpha-spectrin gene is important for understanding erythropoiesis, membrane biogenesis, and spectrin-linked hemolytic anemia. We showed previously that a minimal alpha-spectrin promoter directed low levels of expression only in early erythroid development, indicating elements outside the promoter are required for expression in adult erythro...
متن کاملBinding of serum ferritin to concanavalin A: patients with homozygous beta thalassaemia and transfusional iron overload.
Serum ferritin concentrations have been measured in 124 patients with homozygous beta thalassaemia who were between 2 and 21 years old, had received 11--504 units of blood but had not undergone splenectomy. There were highly significant correlations between serum ferritin concentration and both the amount of blood transfused and alanine amino-transferase (ALT) activity. However, multivariate an...
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ژورنال
عنوان ژورنال: Hematology
سال: 2018
ISSN: 1607-8454
DOI: 10.1080/10245332.2018.1496812